Date published: 2026-6-13

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Cloxacillin sodium salt (CAS 642-78-4)

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Alternate Names:
3-dimethyl-7-oxo-thyl-4-isoxazolecarboxamido)-monosodiumsalt
Application:
Cloxacillin sodium salt is an antibiotic
CAS Number:
642-78-4
Molecular Weight:
457.86
Molecular Formula:
C19H17ClN3NaO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cloxacillin sodium salt is utilized in microbiological research, particularly when studying bacteria that produce penicillinase, an enzyme that degrades penicillin antibiotics. It is a semi-synthetic molecule that falls under the category of beta-lactam antibiotics and is structurally similar to penicillin. In the laboratory, cloxacillin sodium salt can be used to select for penicillin-resistant bacterial strains or to assess the efficacy of beta-lactamase inhibitors. Its role in disrupting bacterial cell wall synthesis by binding to penicillin-binding proteins makes it an important compound in the field of bacterial resistance mechanisms research.


Cloxacillin sodium salt (CAS 642-78-4) References

  1. TREATMENT OF SKIN CONDITIONS OF THE DOG AND CAT USING AMPICILLIN AND CLOXACILLIN SODIUM.  |  TURNER, WT. and LARKIN, PJ. 1965. Vet Rec. 77: 390-3. PMID: 14330221
  2. Spectroscopic and thermodynamic study of charge transfer complexes of cloxacillin sodium in aqueous ethanol medium.  |  Roy, DK., et al. 2005. Spectrochim Acta A Mol Biomol Spectrosc. 61: 2017-22. PMID: 15911386
  3. Incorporation and release of cloxacillin sodium in micelles of poly(styrene-b-2-vinyl pyridine-b-ethylene oxide).  |  Khanal, A. and Nakashima, K. 2005. J Control Release. 108: 150-60. PMID: 16107288
  4. Spectroscopic and thermodynamic study of charge transfer complex formation between cloxacillin sodium and riboflavin in aqueous ethanol media of varying composition.  |  Roy, DK., et al. 2006. Spectrochim Acta A Mol Biomol Spectrosc. 63: 694-9. PMID: 16150635
  5. Preparation and study on the solid inclusion complex of cloxacillin sodium with beta-cyclodextrin.  |  Chao, JB. and Zhang, BT. 2007. Spectrochim Acta A Mol Biomol Spectrosc. 68: 108-12. PMID: 17321790
  6. Flow-injection chemiluminescence determination of cloxacillin in water samples and pharmaceutical preparation by using CuO nanosheets-enhanced luminol-hydrogen peroxide system.  |  Khataee, A., et al. 2015. Spectrochim Acta A Mol Biomol Spectrosc. 134: 210-7. PMID: 25014643
  7. Development and Validation of a Stability-Indicating RP-UPLC Method for Determination of Cloxacillin Sodium in Its Bulk Form and Formulation.  |  Patel, N., et al. 2015. J Chromatogr Sci. 53: 903-8. PMID: 25368408
  8. Validation and application of an HPLC-CAD-TOF/MS method for identification and quantification of pharmaceutical counterions.  |  Ilko, D., et al. 2014. Pharmeur Bio Sci Notes. 2014: 81-91. PMID: 25655245
  9. Solid state adsorption of antibiotics onto sorbitol.  |  Nikolakakis, I. and Newton, JM. 1989. J Pharm Pharmacol. 41: 145-8. PMID: 2568437
  10. Enhanced chemiluminescence of carminic acid-permanganate by CdS quantum dots and its application for sensitive quenchometric flow injection assays of cloxacillin.  |  Khataee, A., et al. 2016. Talanta. 152: 171-8. PMID: 26992508
  11. LC-MS study of the heat degradation of veterinary antibiotics in raw milk after boiling.  |  László, N., et al. 2018. Food Chem. 267: 178-186. PMID: 29934154
  12. Effects of antibiotics on the in vitro ERG of the albino rabbit. Penicillins and cephalosporins antibiotics.  |  Kawasaki, K., et al. 1987. Doc Ophthalmol. 66: 75-84. PMID: 3428073
  13. Therapy of Subclinical Mastitis during Lactation.  |  McDougall, S., et al. 2022. Antibiotics (Basel). 11: PMID: 35203812
  14. Cloxacillin distribution in the rabbit eye after intravenous injection.  |  Salminen, L. 1978. Acta Ophthalmol (Copenh). 56: 11-9. PMID: 580330

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cloxacillin sodium salt, 1 g

sc-319871
1 g
$92.00

Cloxacillin sodium salt, 5 g

sc-319871A
5 g
$230.00