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Brn-2 Antibody (L-17): sc-31983

 |  Datasheet

(Based on data analysis)
  • Brn-2 Antibody (L-17) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of Brn-2 of human origin
  • recommended for detection of Brn-2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
  • blocking peptide, sc-31983 P
  • TransCruz reagent for Gel Supershift and ChIP applications, sc-31983 X, 200 µg/0.1 ml
 

See additional Brn Antibodies including Brn, Brn-1, Brn-2, Brn-3, Brn-3a, Brn-3b, Brn-3c and Brn-5.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   Gel Shift   ChIP   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Brn-2 Antibody (L-17) sc-31983 200 µg/ml $279
Brn-2 (L-17) P sc-31983 P
(peptide)
 100 µg/0.5 ml $61
Brn-2 Antibody (L-17) X sc-31983 X 200 µg/0.1 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Brn-2 siRNA (h) sc-29837 10 µM $258
Brn-2 siRNA (m) sc-29838 10 µM $258
Brn-2 (h)-PR sc-29837-PR 10 µM, 20 µl $23
Brn-2 (m)-PR sc-29838-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Brn-2 shRNA Plasmid (h) sc-29837-SH 20 µg $520
Brn-2 shRNA Plasmid (m) sc-29838-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Brn-2 shRNA (h) Lentiviral Particles sc-29837-V 200 µl $625
Brn-2 shRNA (m) Lentiviral Particles sc-29838-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SK-N-MC Cell Lysate sc-2237 500 µg/200 µl $104
HeLa nuclear extract sc-2120 250 µg/0.05 ml $143
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human POU3F2 5454 6q16.2 NM_005604 P20265
 600494
Mouse Pou3f2 18992 4 A3 P31360
 N/A
 

The Brn family of transcription factors are found in a highly restricted subset of neurons and are critical to the early embryonic development of the central nervous system. Brn-1 and Brn-2 are class III POU domain proteins. Expressed during the development of the forebrain and coexpressed in most layer II-V cortical neurons, Brn-1 and Brn-2 appear to critically control the initiation of radial migration of cortical neurons. Brn-2 is thought to be involved in smooth muscle cell development and differentiation. Brn-3 is a class IV POU domain protein. Three Brn-3 proteins have been described and are designated Brn-3a, Brn-3b and Brn-3c. Brn-3a has two functional transactivating domains, one at the amino terminus and one at the carboxy terminus. While Brn-3a and Brn-3c stimulate transcription, Brn-3b generally functions as a transcriptional repressor. However, Brn-3b, but not Brn-3a, has been shown to regulate the expression of the acetylcholine receptor.