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Bag-1 Antibody (C-20): sc-31682

 |  Datasheet

(Based on data analysis)

  • Bag-1 Antibody (C-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping at the C-terminus of Bag-1 of human origin
  • recommended for detection of Bag-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-31682 P
 

See additional Bag Antibodies including Bag, Bag-1, Bag-2, Bag-3, Bag-5 and BAG-6.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Bag-1 Antibody (C-20) sc-31682 200 µg/ml $279
Bag-1 (C-20) P sc-31682 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Bag-1 siRNA (h) sc-29211 10 µM $258
Bag-1 siRNA (m) sc-29784 10 µM $258
Bag-1 (h)-PR sc-29211-PR 10 µM, 20 µl $23
Bag-1 (m)-PR sc-29784-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Bag-1 shRNA Plasmid (h) sc-29211-SH 20 µg $520
Bag-1 shRNA Plasmid (m) sc-29784-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Bag-1 shRNA (h) Lentiviral Particles sc-29211-V 200 µl $625
Bag-1 shRNA (m) Lentiviral Particles sc-29784-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
HL-60 Whole Cell Lysate sc-2209 500 µg/200 µl $104
mouse testis extract sc-2405 500 µg/200 µl $104
RAW 264.7 Whole Cell Lysate sc-2211 500 µg/200 µl $104
Sol8 Cell Lysate sc-2249 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
F9 Cell Lysate sc-2245 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human BAG1 573 9p13.3 NM_004323 Q99933
 601497
Mouse Bag1 12017 4 A5 Q60739
 N/A
 

The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis, while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. Dimerization of another member of this family, Bad, with Bcl-xL, results in displacement of Bax from Bcl-xL/Bax complexes and restoration of Bax-mediated apoptosis. A Bcl-2-binding protein, designated Bag-1, lacks significant homology with Bcl-2 or with other Bcl-2-related proteins. Bag-1 appears to function to enhance Bcl-2 protection from cell death, suggesting that Bag-1 represents a new type of anti-cell death gene. This also suggests that certain routes of apoptosis induction, previously ascribed to Bcl-2-independent pathways, may instead reflect a requirement for a combination of Bcl-2 and Bag-1.
Bag-1 Antibody (C-20) Data
Click on image to enlarge
sc-31682
Bag-1 (C-20): sc-31682. Western blot analysis of human recombinant Bag-1 fusion protein.
sc-31682
Bag-1 (C-20): sc-31682. Western blot analysis of human recombinant Bag-1 fusion protein.
sc-31682
Bag-1 (C-20): sc-31682. Western blot analysis of Bag-1 expression in non-transfected: sc-117752 (A) and human Bag-1 transfected: sc-112723 (B) 293T whole cell lysates.
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