epitope mapping within an internal region of Eg5 of human origin
recommended for detection of kinesin-related motor protein Eg5 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and canine
Eg5 Background Information Eukaryotes contain a superfamily of microtubule-based motor proteins comprising kinesin and a number of related proteins that are thought to participate in various forms of intracellular motility, including cell division and organelle transport. Eg5 (also known as kinesin-like protein KIF11, or TRIP5) is a slow, plus-end-directed microtubule-based motor of the BimC kinesin family that is essential for bipolar spindle formation during eukaryotic cell division. When the expression of Eg5 is blocked, centrosome migration halts and cells are arrested in mitosis with monoastral microtubule arrays. Eg5 is phosphorylated on serine during S phase and on both serine and Thr-927 during mitosis, which regulates the association of Eg5 with the spindle apparatus (probably during early prophase). Eg5 is also known to be a member of the thyroid receptor interacting protein (Trip) family, and interacts with the thyroid hormone receptor only in the presence of thyroid hormone.
Eg5 (K-20) Product Citations
See how others have used Eg5 (K-20): sc-31643 antibody and or Eg5 (K-20) antibody conjugates.
