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GABAA Rβ1 (D-17) Antibody: sc-31424 |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an N-terminal extracellular domain of GABAA Rβ1 of human origin
- recommended for detection of GABAA Rβ1 and, to a lesser extent, GABAA Rβ2 and GABAA Rβ3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine and porcine
- blocking peptide, sc-31424 P
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GABAA Rβ1 Background Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rå1-6, GABAA R ∫1-3, GABAA R©1-3, GABAA R∂, GABAA Ré, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1å and GABAB R1∫. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action. |
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GABAA Rβ1 (D-17)
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GABAA Rb1 (D-17): sc-31424. Western blot analysis of GABAA Rb1 expression in mouse cerebellum (A), rat cerebellum (B), mouse brain (C) and rat brain (D) tissue extracts.
GABAA Rβ1 (D-17): sc-31424. Western blot analysis of GABAA Rβ3 expression in mouse testis tissue extract.
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