Date published: 2026-7-4

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IRE1 Antibodies

Santa Cruz Biotechnology features a diverse variety of IRE1 monoclonal antibodies for research focused on understanding cellular stress responses. IRE1 monoclonal antibodies are suitable for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IRE1 is a critical component of the unfolded protein response (UPR), playing a vital role in maintaining cellular homeostasis under stress conditions. IRE1 functions in the regulation of gene expression and apoptosis, making it an important target for studies related to diseases such as cancer and neurodegeneration. Understanding IRE1 mechanisms can provide insights into therapeutic strategies aimed at modulating the UPR. Researchers worldwide utilize IRE1 monoclonal antibodies to investigate cellular stress pathways and their impact on disease progression. Advanced research techniques supported by IRE1 monoclonal antibodies enable detailed analysis of protein interactions and signaling cascades. Santa Cruz Biotechnology monoclonal antibodies for IRE1 research contribute to advancing scientific understanding of stress response pathways and potential therapeutic applications.

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IRE1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

IRE1α Antibody (B-12)

sc-390960mouse IgG1 κ371-560 (h)WB, IP, IF, ELISAm, r, h
68
(27)

IRE1α Antibody (YB-17)

sc-100772mouse IgG2a κ401-500 (h)WB, IP, IF, ELISAh
1
(3)

IRE1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRE1α siRNA (h)

sc-40705hGene SilencingN/A
41
(0)

IRE1α shRNA Plasmid (h)

sc-40705-SHhGene SilencingPuromycin
41
(0)

IRE1α shRNA (h) Lentiviral Particles

sc-40705-VhGene SilencingPuromycin
41
(0)

IRE1α siRNA (m)

sc-40706mGene SilencingN/A
6
(0)

IRE1α shRNA Plasmid (m)

sc-40706-SHmGene SilencingPuromycin
6
(0)

IRE1α shRNA (m) Lentiviral Particles

sc-40706-VmGene SilencingPuromycin
6
(0)

IRE1α siRNA (r)

sc-270028rGene SilencingN/A
3
(0)

IRE1α shRNA Plasmid (r)

sc-270028-SHrGene SilencingPuromycin
3
(0)

IRE1α shRNA (r) Lentiviral Particles

sc-270028-VrGene SilencingPuromycin
3
(0)

IRE1β siRNA (h)

sc-40707hGene SilencingN/A0
(0)

IRE1β shRNA Plasmid (h)

sc-40707-SHhGene SilencingPuromycin0
(0)

IRE1β shRNA (h) Lentiviral Particles

sc-40707-VhGene SilencingPuromycin0
(0)

IRE1β siRNA (m)

sc-40708mGene SilencingN/A0
(0)

IRE1β shRNA Plasmid (m)

sc-40708-SHmGene SilencingPuromycin0
(0)

IRE1β shRNA (m) Lentiviral Particles

sc-40708-VmGene SilencingPuromycin0
(0)

IRE1 CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IRE1α CRISPR/Cas9 KO Plasmid (h)

sc-400576Gene Knockouth0
(2)

IRE1α HDR Plasmid (h)

sc-400576-HDRHomology Directed Repairh0
(2)

IRE1α CRISPR/Cas9 KO Plasmid (m)

sc-429758Gene Knockoutm0
(0)

IRE1α HDR Plasmid (m)

sc-429758-HDRHomology Directed Repairm0
(0)

IRE1β CRISPR/Cas9 KO Plasmid (m)

sc-424138Gene Knockoutm0
(0)

IRE1 CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IRE1α Double Nickase Plasmid (h)

sc-400576-NICGene Knockouth0
(0)

IRE1α Double Nickase Plasmid (h2)

sc-400576-NIC-2Gene Knockouth0
(0)

IRE1α Double Nickase Plasmid (m)

sc-429758-NICGene Knockoutm0
(0)

IRE1α Double Nickase Plasmid (m2)

sc-429758-NIC-2Gene Knockoutm0
(0)

IRE1 CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

IRE1α CRISPR Activation Plasmid (h)

sc-400576-ACTGene Activationh0
(0)

IRE1α Lentiviral Activation Particles (h)

sc-400576-LACGene Activationh0
(0)