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CYM 5442 hydrochloride (CAS 1094042-01-9)

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Application:A potent, brain penetrant, and selective EDG-1 (S1P1) agonist
CAS Number:1094042-01-9
Purity:≥99%
Molecular Weight:445.94
Molecular Formula:C23H27N3O4•HCl
Refer to Certificate of Analysis for lot specific data (including water content).
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CYM 5442 hydrochloride sc-311309 10 mg $179
CYM 5442 hydrochloride sc-311309A 50 mg $825
Description
CYM 5442 hydrochloride is a potent and selective EDG-1 (S1P1) agonist in vitro (EC50 = 1.35 nM). Shown to activate S1P1-mediated p42/p44 MAPK phosphorylation in CHO-K1 cells transfected with S1P1. Induces acute lymphopenia in mice. Brain penetrant.
Technical Information
Physical State:Solid
Solubility:Soluble in water (10 mM), and DMSO (100 mM).
Storage:Store at -20° C
IC50:S1P1: EC5050 = 1.35 nM
Safety and Reference Information
SMILES:Cl.OCCNC1CCC2C(CCCC12)C1NOC(N1)C1CCC(OCC)C(OCC)C1
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Gonzalez-Cabrera, P.J., et al. 2008. Mol. Pharmacol. 74: 1308-1318. PMID: 18708635
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Certificate of Analysis

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