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home » Transport and Trafficking » Hemoglobin Antibody / Hemoglobin Antibodies » Hemoglobin α (V-13): sc-31109

Hemoglobin α (V-13) Antibody: sc-31109

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping near the N-terminus of Hemoglobin α of human origin
  • recommended for detection of Hemoglobin α of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
  • blocking peptide, sc-31109 P
 
Additional Hemoglobin Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human HBA1 3039 16p13.3 NM_000558 P69905
 141800
Human HBA2 3040 16p13.3 NM_000517 P69905
 141850
Mouse Hba-a1 15122 11 A4 P01942
 N/A
Mouse Hba-a2 110257 11 A4 NP_001077424
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Hemoglobin α (V-13) sc-31109 200 µg/ml $279
Hemoglobin α (V-13) P sc-31109 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Hemoglobin α siRNA (h) sc-41230 10 µM $258
Hemoglobin α siRNA (m) sc-41231 10 µM $258
Hemoglobin α (h)-PR sc-41230-PR 10 µM $23
Hemoglobin α (m)-PR sc-41231-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Hemoglobin α shRNA Plasmid (h) sc-41230-SH 20 µg $520
Hemoglobin α shRNA Plasmid (m) sc-41231-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Hemoglobin α shRNA (h) Lentiviral Particles sc-41230-V 200 µl $625
Hemoglobin α shRNA (m) Lentiviral Particles sc-41231-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TF-1 Cell Lysate sc-2412 500 µg/200 µl $104
HEL 92.1.7 Cell Lysate sc-2270 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
mouse heart extract sc-2254 500 µg/200 µl $104

Hemoglobin α Background Information
Hemoglobin (Hgb) is coupled to four iron-binding, methene-linked tetrapyrrole rings (heme). The å (16p13.3; 5'-Ω-pseudoz-pseudo å2-pseudo å1-å2-å1-œ1-3') and ∫ (11p15.5) globin loci determine the basic hemoglobin structure. The globin portion of hemoglobin consists of two å chains and two ∫ chains arranged in pairs forming a tetramer. Each of the four globin chains covalently associates with a heme group. The bonds between å and ∫ chains are weaker than between similar globin chains, thereby forming a cleavage plane that is important for oxygen binding and release. High affinity for oxygen occurs upon relaxation of the å1-∫2 cleavage plane. When the two å1-∫2 interfaces are closely bound, hemoglobin has a low affinity for oxygen. Hb A, which contains two å chains plus two ∫ chains, comprises 97% of total circulating hemoglobin. The remaining 3% of total circulating hemoglobin is comprised of Hb A-2, which consists of two å chains plus two ∂ chains, and fetal hemoglobin (Hb F), which consists of two å chains together with two © chains.
Hemoglobin α (V-13)
Click on image to enlarge
sc-31109
Hemoglobin α (V-13): sc-31109. Immunofluorescence staining of methanol-fixed K-562 cells showing cytoplasmic localization.
sc-31109
Hemoglobin α (V-13): sc-31109. Western blot analysis of Hemoglobin α expression in HEL 92.1.7 whole cell lysate.
sc-31109
Hemoglobin α (V-13): sc-31109. Western blot analysis of Hemoglobin α expression in K-562 whole cell lysate.
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