claudin-11 (I-18) Antibody: sc-30990

claudin-11 Background Information
The claudin superfamily consists of many structurally related proteins in humans. These proteins, which include claudin-1 through -18, are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-11 is an oligodendrocyte-specific protein that is expresed in the tight junctions of Sertoli cells and myelin sheaths in mice. In addition, claudin-11 is expressed in the epithelial tight junctions of the choroid plexus. The human claudin-11 gene maps to chromosome 3q26.2-q26.3.