santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Transcription Regulators » HP1 Antibody / HP1 Antibodies » HP1α (K-16): sc-30743

HP1α (K-16) Antibody: sc-30743

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping within an internal region of HP1α of human origin
  • recommended for detection of HP1α of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with HP1β and HP1γ; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-30743 P
 
Additional HP1 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CBX5 23468 12q13.13 NM_012117 P45973
 604478
Mouse Cbx5 12419 15 F3 Q61686
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
HP1α (K-16) sc-30743 200 µg/ml $279
HP1α (K-16) P sc-30743 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HP1α siRNA (h) sc-37737 10 µM $258
HP1α siRNA (m) sc-37738 10 µM $258
HP1α (h)-PR sc-37737-PR 10 µM $23
HP1α siRNA (m) sc-37738-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HP1α shRNA Plasmid (h) sc-37737-SH 20 µg $520
HP1α shRNA Plasmid (m) sc-37738-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HP1α shRNA (h) Lentiviral Particles sc-37737-V 200 µl $625
HP1α shRNA (m) Lentiviral Particles sc-37738-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa nuclear extract sc-2120 1000 µg $143
HP1α (h): 293 Lysate sc-110608 100µg/200µl $205

HP1α Background Information
Chromatin assembly factor-1 (CAF-1) is a multisubunit protein complex that comprises three polypeptide subunits known as p150, p60, and p48. CAF-1 is a nucleosome assembly factor that deposits newly synthesized and acetylated histones H3/H4 into nascent chromatin during DNA replication. The p150 subunit of CAF-1 also supports the maintenance of heterochromatin, which requires the synthesis of both new histones and heterochromatin proteins and their orderly assembly during DNA replication. Heterochromatin is characterized as densely coiled chromatin that generally replicates late during S phase, has a low gene density, and contains large blocks of repetitive DNA that is relatively inaccessible to DNA-modifying reagents. In late S phase, p150 directly associates with heterochromatin associated proteins 1 (HP1å, HP1∫ and HP1©). As cells prepare for mitosis, CAF-1 p150 and some HP1 progressively dissociate from heterochromatin, coinciding with the phosphorylation of Histone H3. The HP1 proteins reassociate with chromatin at the end of mitosis, as Histone H3 is dephosphorylated.