epitope mapping within an internal region of hnRNP U of human origin
recommended for detection of hnRNP U of mouse, rat and human origin by ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
hnRNP U Background Information RNA polymerase II transcripts are complexed with hnRNP (heterogeneous nuclear ribonucleoprotein) proteins, which are involved in several aspects of hnRNA maturation and transport. The hnRNP particle U (also designated SP120 and SAF-A for scaffold attachment factor) is an abundant nucleoplasmic phosphoprotein and the largest of the major hnRNP proteins. hnRNP U is specifically involved in pre-mRNA processing and is directly bound to both RNA and DNA. Specifically, hnRNP U has a high affinity to the SAR (scaffold attachment region) of DNA . hnRNP U also functions as an RNA polymerase elongation inhibitor by inhibiting TFIIH-mediated phosphorylation of the carboxy-terminal domain of Pol II. Identical to GRIP120, hnRNP U also associates with glucocorticoid receptors to inhibit glucocorticoid induction.
