hnRNP E2 (H-15) Antibody: sc-30725

hnRNP E2 Background Information
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription, pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation (1,2). They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II (1). There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome (2,3). The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm, such as hnRNP E1 and E2 (2,4). hnRNP E1 may function in the cytoplasm as a translational regulatory protein, while hnRNP E2 stabilizes mRNA to enhance polioviral mRNA translation (2,5). hnRNP M is involved in pre-mRNA splicing and in stress-induced transient splicing arrest (6,7).