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hnRNP E2 (N-16) Antibody: sc-30723 |
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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of hnRNP E2 of human origin
- recommended for detection of hnRNP E2 and, to a lesser extent, hnRNP E1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-30723 P
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hnRNP E2 Background Information
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription, pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation (1,2). They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II (1). There are approximately 20 known hnRNP proteins, and their complexes are the major constituents of the spliceosome (2,3). The majority of hnRNP proteins components are localized to the nucleus; however some shuttle between the nucleus and the cytoplasm, such as hnRNP E1 and E2 (2,4). hnRNP E1 may function in the cytoplasm as a translational regulatory protein, while hnRNP E2 stabilizes mRNA to enhance polioviral mRNA translation (2,5). hnRNP M is involved in pre-mRNA splicing and in stress-induced transient splicing arrest (6,7).
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hnRNP E2 (N-16)
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hnRNP E2 (N-16): sc-30723. Western blot analysis of hnRNP E2 expression in Sol8 nuclear extract.
hnRNP E2 (N-16): sc-30723. Western blot analysis of hnRNP E2 expression in non-transfected: sc-117752 (A) and human hnRNP E2 transfected: sc-111924 (B) 293T whole cell lysates. |
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