epitope mapping near the N-terminus of Hus1 of human origin
recommended for detection of Hus1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
Hus1 Background Information DNA damage or incomplete replication of DNA results in inhibition of cell cycle progression at the G1-S or G2-M checkpoints by conserved regulatory mechanisms. Chk1, Rad9 and Hus1 are involved in regulation of cell cycle arrest at the G2 checkpoint. Chk1 functions as an essential component in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response to DNA damage, which inhibits mitosis. Hus1 and Rad9 exhibit conserved function in fission yeast and higher eukaryotes. Hus1 has been shown to be phosphorylated in response to DNA damage, a process which requires rad checkpoint genes. Rad9 is thought to be a candidate tumor suppressor gene because it is localized to human chromosome 11q13.1-13.2, which is a region containing a number of tumor suppressor loci.
