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p107 Antibody (D-14): sc-30540

 |  Datasheet

(Based on data analysis)
  • p107 Antibody (D-14) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping near the C-terminus of p107 of human origin
  • recommended for detection of p107 of human and, to a lesser extent, mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-30540 P
 

See additional p107 Antibodies.

Also see p107 Inhibitors for functional analysis of cellular responses to p107.


Ordering InformationGene Info
Recommended Support Products:
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WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p107 Antibody (D-14) sc-30540 200 µg/ml $279
p107 (D-14) P sc-30540 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p107 siRNA (h) sc-29423 10 µM $258
p107 (h)-PR sc-29423-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p107 shRNA Plasmid (h) sc-29423-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
p107 shRNA (h) Lentiviral Particles sc-29423-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SK-BR-3 Cell Lysate sc-2218 500 µg/200 µl $104
C32 Whole Cell Lysate sc-2205 500 µg/200 µl $104
MCF7 Whole Cell Lysate sc-2206 500 µg/200 µl $104
Y79 Cell Lysate sc-2240 500 µg/200 µl $104
MM-142 Cell Lysate sc-2246 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human RBL1 5933 20q11.23 NM_002895, NM_183404 P28749
 116957
Mouse Rbl1 19650 2 H1 Q64701
 N/A
 

The human retinoblastoma gene product plays an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. pRb and the structurally related p107 form complexes with E2F, a transcription factor originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Moreover, pRB and p107 share a high degree of structural homology in the adenovirus E1A binding domain (i.e. “pocket region”) that is believed to play a primary role in the function of these proteins. A protein designated p130 shows a high degree of identity with pRb and p107 and also possesses a pocket region.