santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Transcription Regulators » IRF Antibody / IRF Antibodies » IRF-6 (C-18): sc-30451

IRF-6 (C-18) Antibody: sc-30451

  |  Datasheet
  • goat polyclonal IgG, 200µg/ml
  • epitope mapping within an internal region of IRF-6 of human origin
  • recommended for detection of IRF-6 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-30451 P
 
Additional IRF Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human IRF6 3664 1q32.2 NM_006147 O14896
 608864
Mouse Irf6 54139 1 H6 P97431
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-6 (C-18) sc-30451 200 µg/ml $279
IRF-6 (C-18) P sc-30451 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-6 siRNA (h) sc-105582 10 µM $258
IRF-6 siRNA (m) sc-146286 10 µM $258
IRF-6 (h)-PR sc-105582-PR 10 µM $23
IRF-6 (m)-PR sc-146286-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-6 shRNA Plasmid (h) sc-105582-SH 20 µg $520
IRF-6 shRNA Plasmid (m) sc-146286-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
IRF-6 shRNA (h) Lentiviral Particles sc-105582-V 200 µl $625
IRF-6 shRNA (m) Lentiviral Particles sc-146286-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Jurkat nuclear extract sc-2132 1000 µg $143

IRF-6 Background Information
Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-å and ∫) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-å and interferon-∫ genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3© p48 and IFN consensus sequence-binding protein (ICSBP).