p-ACCβ (Ser 219/Ser 221)-R Antibody: sc-30446-R

ACCβ Background Information
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system, which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCå (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC∫ (ACC2) is thought to control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. The gene encoding ACC∫ maps to human chromosome 12 and encodes a mitochondiral protein exressed in heart and skeletal muscle. The catalytic core of ACC∫ is homologous to that of the ACCå, except for an additional peptide of about 150 amino acids at the N terminus.