epitope corresponding to phosphorylated Thr 48 of B-ATF of human origin
recommended for detection of Thr 48 phosphorylated B-ATF of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
B-ATF Background Information B-ATF is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors (1-5). The leucine zipper of B-ATF mediates dimerization with members of the Jun family of proteins (1). The B-ATF protein does not homodimerize efficiently, but rather forms a heterodimer preferentially with c-Jun (4). The B-ATF/c-Jun protein complex can interact with DNA containing a consensus binding site for AP-1, suggesting that B-ATF functions as a tissue-specific modulator of the AP-1 transcription complex in human cells (3). B-ATF also associates with IFP35, a leucine zipper protein that translocates to the nucleus following IFN treatment (4). The gene encoding B-ATF, also designated SFA-2, is strongly expressed in mature T and B lymphocytes, and is up-regulated after transformation by human T-cell leukemia virus type I (5). Phosphorylation of BATF on Ser43 and Thr48 regulates DNA binding.
