epitope mapping within an internal region of KLF3 of human origin
recommended for detection of KLF3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-30380 X, 200 µg/0.1 ml
KLF3 Background Information Krüppel-like factors (KLFs) comprise a family of evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation and embryogenesis. Individual members of the Sp1-like/KLF family can function either as activators or repressors, depending on which promoter they bind and the coregulators with which they interact. KLF6, also designated Zf9 or CPBP (core promoter-binding protein), and KLF3 are Krüppel-like zinc finger containing transcription factors. KLF6 is rapidly induced during hepatic stellate cell activation and transactivates a reporter gene driven by the collagen I promoter, suggesting KLF6 plays a role in the response to tissue injury. KLF3 may play a role in hematopoiesis.
