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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the N-terminus of Aph-1 of human origin
- recommended for detection of Aph-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-30240 P
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Ordering Information
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
APH1A |
51107 |
1q21.2 |
NM_016022 |
Q96BI3
|
607629 |
| Mouse |
Aph1a |
226548 |
3 F2.1 |
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Q8BVF7
|
N/A |
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Aph-1 Background Information
Four proteins comprise the ©-secretase complex: presenilin, nicastrin, Aph-1, and PEN-2. Together, these proteins mediate cell surface signaling pathways for a variety of type I membrane proteins, notably amyloid-beta precursor protein, a protein implicated in the development of Alzheimer’s disease, via intramembrane proteolysis. The proteins assemble into a proteolytically active complex in the Golgi/trans-Golgi network (TGN) compartments. Assembly leads to autocleavage of presenilin into two subunits to create the active site of ©-secretase, an important step in understanding the mechanisms involved in the etiology and possible treatment of Alzheimer’s disease. |
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Aph-1 (N-20)
Click on image to enlarge
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Aph-1 (N-20): sc-30240. Western blot analysis of Aph-1 expression in HeLa whole cell lysate.
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