Date published: 2025-10-17

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Xanthohumol from hop (Humulus lupulus) (CAS 6754-58-1)

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Application:
Xanthohumol from hop (Humulus lupulus) is an inhibitor of cytochrome P450 enzymes
CAS Number:
6754-58-1
Molecular Weight:
354.40
Molecular Formula:
C21H22O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Xanthohumol is a prenylated chalcone found in the hop plant (Humulus lupulus). It functions as a potent antioxidant, exhibiting the ability to scavenge free radicals and reduce oxidative stress within biological systems. Xanthohumol may modulate various signaling pathways involved in inflammation, exerting anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators. At the molecular level, it interacts with enzymes and transcription factors to regulate gene expression, impacting cellular processes related to oxidative damage and inflammation. Xanthohumol possesses anti-proliferative properties, affecting cell cycle progression and inducing apoptosis in certain cell types. Its mechanism of action involves targeting specific molecular pathways involved in cell growth and survival, making it a subject of interest in various experimental applications.


Xanthohumol from hop (Humulus lupulus) (CAS 6754-58-1) References

  1. Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.).  |  De Keukeleire, J., et al. 2003. J Agric Food Chem. 51: 4436-41. PMID: 12848522
  2. Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.  |  Wang, Q., et al. 2004. Antiviral Res. 64: 189-94. PMID: 15550272
  3. Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes.  |  Nikolic, D., et al. 2005. J Mass Spectrom. 40: 289-99. PMID: 15712367
  4. Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites.  |  Gerhäuser, C. 2005. Mol Nutr Food Res. 49: 827-31. PMID: 16092071
  5. Sensitive electrochemical detection method for alpha-acids, beta-acids and xanthohumol in hops (Humulus lupulus L.).  |  Kac, J. and Vovk, T. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 850: 531-7. PMID: 17142112
  6. Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.).  |  Keukeleire, JD., et al. 2007. J Agric Food Chem. 55: 61-6. PMID: 17199314
  7. Determination of xanthohumol in hops (Humulus lupulus L.) by nonaqueous CE.  |  Kac, J., et al. 2007. Electrophoresis. 28: 965-9. PMID: 17309054
  8. Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines.  |  Ho, YC., et al. 2008. Phytother Res. 22: 1465-8. PMID: 18814205
  9. Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes.  |  Lupinacci, E., et al. 2009. J Agric Food Chem. 57: 7274-81. PMID: 19634869
  10. Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus).  |  Liu, M., et al. 2015. Molecules. 20: 754-79. PMID: 25574819
  11. Preparative isolation and purification of xanthohumol from hops (Humulus lupulus L.) by high-speed counter-current chromatography.  |  Chen, QH., et al. 2012. Food Chem. 132: 619-23. PMID: 26434340
  12. Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity.  |  Luzak, B., et al. 2017. Arch Physiol Biochem. 123: 54-60. PMID: 27855519
  13. Effect of Dietary Purified Xanthohumol from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose Level, and Lipid Metabolism in KK-Ay Mice.  |  Takahashi, K. and Osada, K. 2017. J Oleo Sci. 66: 531-541. PMID: 28413193

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Xanthohumol from hop (Humulus lupulus), 5 mg

sc-301982
5 mg
$354.00