Molecular structure of Xanthohumol from hop (Humulus lupulus), CAS Number: 6754-58-1
Xanthohumol from hop (Humulus lupulus) (CAS 6754-58-1)
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Application:
Xanthohumol from hop (Humulus lupulus) is an inhibitor of cytochrome P450 enzymes
CAS Number:
6754-58-1
Molecular Weight:
354.40
Molecular Formula:
C21H22O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Xanthohumol is a prenylated chalcone found in the hop plant (Humulus lupulus). It functions as a potent antioxidant, exhibiting the ability to scavenge free radicals and reduce oxidative stress within biological systems. Xanthohumol may modulate various signaling pathways involved in inflammation, exerting anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators. At the molecular level, it interacts with enzymes and transcription factors to regulate gene expression, impacting cellular processes related to oxidative damage and inflammation. Xanthohumol possesses anti-proliferative properties, affecting cell cycle progression and inducing apoptosis in certain cell types. Its mechanism of action involves targeting specific molecular pathways involved in cell growth and survival, making it a subject of interest in various experimental applications.
Xanthohumol from hop (Humulus lupulus) (CAS 6754-58-1) References
- Formation and accumulation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol during flowering of hops (Humulus lupulus L.). | De Keukeleire, J., et al. 2003. J Agric Food Chem. 51: 4436-41. PMID: 12848522
- Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus. | Wang, Q., et al. 2004. Antiviral Res. 64: 189-94. PMID: 15550272
- Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes. | Nikolic, D., et al. 2005. J Mass Spectrom. 40: 289-99. PMID: 15712367
- Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites. | Gerhäuser, C. 2005. Mol Nutr Food Res. 49: 827-31. PMID: 16092071
- Sensitive electrochemical detection method for alpha-acids, beta-acids and xanthohumol in hops (Humulus lupulus L.). | Kac, J. and Vovk, T. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 850: 531-7. PMID: 17142112
- Relevance of organic farming and effect of climatological conditions on the formation of alpha-acids, beta-acids, desmethylxanthohumol, and xanthohumol in hop (Humulus lupulus L.). | Keukeleire, JD., et al. 2007. J Agric Food Chem. 55: 61-6. PMID: 17199314
- Determination of xanthohumol in hops (Humulus lupulus L.) by nonaqueous CE. | Kac, J., et al. 2007. Electrophoresis. 28: 965-9. PMID: 17309054
- Inhibitory effects of xanthohumol from hops (Humulus lupulus L.) on human hepatocellular carcinoma cell lines. | Ho, YC., et al. 2008. Phytother Res. 22: 1465-8. PMID: 18814205
- Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. | Lupinacci, E., et al. 2009. J Agric Food Chem. 57: 7274-81. PMID: 19634869
- Pharmacological profile of xanthohumol, a prenylated flavonoid from hops (Humulus lupulus). | Liu, M., et al. 2015. Molecules. 20: 754-79. PMID: 25574819
- Preparative isolation and purification of xanthohumol from hops (Humulus lupulus L.) by high-speed counter-current chromatography. | Chen, QH., et al. 2012. Food Chem. 132: 619-23. PMID: 26434340
- Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity. | Luzak, B., et al. 2017. Arch Physiol Biochem. 123: 54-60. PMID: 27855519
- Effect of Dietary Purified Xanthohumol from Hop (Humulus lupulus L.) Pomace on Adipose Tissue Mass, Fasting Blood Glucose Level, and Lipid Metabolism in KK-Ay Mice. | Takahashi, K. and Osada, K. 2017. J Oleo Sci. 66: 531-541. PMID: 28413193
Inhibitor of:
API5, Brn-2, Brn-3b, CYP, DGAT, DGAT2L3, DGAT2L4, DGAT2L6, DNA Polymerase, EG216818, FXR1, PKB Kinase, RAP1, RBP-Jκ, RGS6, Ros, RUNX2, SCD, Spatacsin, SPEN, Spi13, T2R8, TRAF1, Trav9n-3, TRM12, USF-2, V1RF2, V1RF3, V1RF5, and VCP.Activator of:
DNER, P23, Ran BP-2, TAB3, Tollip, UGT1A9, and USP9X.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Xanthohumol from hop (Humulus lupulus), 5 mg | sc-301982 | 5 mg | $354.00 |