WAY 200070 (CAS 440122-66-7)

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Application:	A selective ERβ agonist
CAS Number:	440122-66-7
Purity:	≥98%
Molecular Weight:	306.11
Molecular Formula:	C₁₃H₈BrNO₃

Ordering Information

Product Name	Catalog #	Unit	Price	Qty	Add
WAY 200070	sc-301977	10 mg	$108
WAY 200070	sc-301977A	50 mg	$440

This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

Description

A selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC₅₀ values are 2 and 155 nM for ERβ and ERα respectively). Has been shown to display antianxiolytic and antidepressive effects in vivo.

Technical Information

Appearance:	Off-white
Solubility:	Soluble in DMSO (≥20 mg/ml), and ethanol (2.5 mg/ml).
Storage:	Store at room temperature
Density:	~1.72 g/cm³ (Predicted)
Refractive Index:	n²⁰_D ~1.72 (Predicted)
IC50:	ERα: IC₅₀ = 1.7 nM (mouse); ERα: EC₅₀50 = 155 nM (mouse); ERβ: IC₅₀ = 1.2 nM (rat); ERβ: IC₅₀ = 1.4 nM (human); ERβ: EC₅₀50 = 2 nM (mouse)

Safety and Reference Information

Transport:	UN 2811, Class 6.1, Packing group III
WGK Germany:	3
PubChem CID:	9861330
SMILES:	Oc1ccc(cc1)c1oc2c(Br)cc(O)cc2n1

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

Malamas et al (2004) Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-b ligands. J.Med.Chem. 47 5021. Hughes et al (2008) WAY-200070, a selective agonist of estrogen receptor beta as a potential novel anxiolytic/antidepressant agent. Neuropharmacology 54 1136. Clipperton et al (2008) Differential effects of estrogen receptor alpha and beta specific agonists on social learning of food preferences in female mice. Neuropsychopharmacology 33 2362.

SDS

Datasheet/SDS