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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 246-310 mapping within an internal region of CoREST of human origin
- recommended for detection of CoREST of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
RCOR1 |
23186 |
14q32.31 |
NM_015156 |
Q9UKL0
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607675 |
| Mouse |
Rcor1 |
217864 |
12 F1 |
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Q8CFE3
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N/A |
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CoREST Background Information
NRSF (neuron-restrictive silencer factor, also designated XBR and REST for RE1-silencing factor) is a silencer protein that represses neuronal gene transcription in non-neuronal cells. NRSF-mediated repression requires histone deacetylase activity because repressed genes are associated with hypoacetylated chromatin. HDAC is recruited to the NRSF repressor complex by two co-repressors, Sin3A and CoREST. CoREST interacts with a single zinc finger motif in the carboxy-terminal repressor domain of NRSF, whereas Sin3A interacts with NRSF’s amino-terminal repressor domain. In addition, CoREST interacts with HDAC through a SANT domain, which is found in other HDAC interacting proteins such as NCoR, MTA1 and MTA2. CoREST is an integral component of the NRSF repressor complex. Its functionality has been conserved in several species, including human, mouse, Xenopus, and C. elegans.
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CoREST (H-65)
Click on image to enlarge
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CoREST (H-65): sc-30189. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
CoREST (H-65): sc-30189. Western blot analysis of CoREST expression in MOLT-4 nuclear extract.
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