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Endophilin (H-300) Antibody: sc-30101 |
| Datasheet |
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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 53-352 mapping at the C-terminus of Endophilin I of human origin
- recommended for detection of Endophilin I, II, and III of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
SH3GL2 |
6456 |
9p22.2 |
NM_003026 |
Q99962
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604465 |
| Mouse |
Sh3gl2 |
20404 |
4 C4 |
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Q62420
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N/A |
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Endophilin Background Information The endophilins comprise a family of three SH3 domain-containing proteins designated Endophilin I, II and III, or alternatively known as SH3P4, SH3P8 and SH3P13, respectively. These proteins associate with Amphiphysin, Synaptojanin and Dynamin and are implicated in presynaptic vesicle trafficking at nerve terminals. The expression patterns of the endophilins are consistent with their cellular functions at the neuronal synapse, as Endophilin I is ex-
pressed only in the brain. Both Endophilin II and Endophilin III are detected in a variety of tissues. Endophilin I is also implicated in modulating G protein-coupled receptor signaling by functioning as an adapter protein and directing ?1 adrenergic receptors to the endocytic machinery. |
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Endophilin (H-300)
Click on image to enlarge
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Endophilin I-III (H-300): sc-30101. Western blot analysis of Endophilin I-III expression in mouse brain tissue extract.
Endophilin I-III (H-300): sc-30101. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
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