Flightless I (H-300) Antibody: sc-30046

Flightless I Background Information
The Drosophila melanogaster Flightless I gene is required for normal cellularization of the syncytial blastoderm in early embryogenesis and in the structural organization of indirect flight muscle. The Flightless I protein contains an Actin-binding domain with homology to the gelsolin family and is likely to be involved in Actin cytoskeletal rearrangements. Flightless I also contains an N-terminal leucine-rich repeat protein-protein interaction domain. The Flightless I protein localizes predominantly to the nucleus and translocates to the cytoplasm following serum stimulation. In cells stimulated to migrate, the Flightless I protein co-localizes with b-tubulin- and Actin-based structures. The human FLI gene is mapped within the Smith-Magenis microdeletion region of chromosome 17 at 17p11.2. Smith-Magenis syndrome is characterized by short stature, brachydactyly, developmental delay, dysmorphic features, sleep disturbances and behavioral problems.