CRLR (H-42) Antibody: sc-30028

CRLR Background Information
Adrenomedullin (ADM) is a hypotensive peptide that belongs to a peptide superfamily, which includes the Calcitonin gene-related peptide (CGRP), a potent vasodilator, and amylin (1,2). Three distinct receptors have the ability to bind ADM and are designated ADM receptor (also designated L1), RDC-1 and calcitonin receptor-like receptor (CRLR) (3). CRLR associates with receptor activity-modifying proteins (RAMPs), which determine the specificity of CRLR binding (2). Co-expression with RAMP1 results in CRLR binding to CGRP, whereas association with RAMP2 or RAMP3 results in ADM binding (2). These RAMP proteins mediate the level of glycosylation of CRLR, which in turn, determines the specificity of the receptors. (4) CRLR is expressed in heart and blood vessels, which suggests its involvement in vasodilation, smooth muscle relaxation and angiogenesis (5,6). RDC-1 is also expressed in heart as well as lung and primarily binds CGRP (6,7).