Solasodine (CAS 126-17-0)
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Solasodine, a steroidal alkaloid primarily found in plants in the Solanaceae family, such as nightshade, displays a pivotal role in biochemical research due to its unique interaction with cellular membranes and signaling pathways. This compound serves as a precursor in the biosynthesis of complex steroidal compounds, leveraging its framework to delve into the molecular intricacies of steroid action within biological systems. Its mechanism, characterized by the modulation of membrane integrity and the influence on lipid bilayer properties, provides useful for scientists to explore the fundamental processes of cell signaling and membrane dynamics. Through its application in the synthesis of steroids, solasodine aids in the elucidation of cellular processes and the development of novel biochemical methodologies, enhancing our understanding of biological mechanisms at the molecular level.
Solasodine (CAS 126-17-0) References
- Anticonvulsant activity of solasodine isolated from Solanum sisymbriifolium fruits in rodents. | Chauhan, K., et al. 2011. Pharm Biol. 49: 194-9. PMID: 21062107
- Solasodine Induces Apoptosis, Affects Autophagy, and Attenuates Metastasis in Ovarian Cancer Cells. | Xu, XH., et al. 2017. Planta Med. 83: 254-260. PMID: 27462871
- Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression. | Shen, KH., et al. 2017. Chem Biol Interact. 268: 129-135. PMID: 28283413
- Aglycone solanidine and solasodine derivatives: A natural approach towards cancer. | Hameed, A., et al. 2017. Biomed Pharmacother. 94: 446-457. PMID: 28779706
- Some observations on solasodine reactivity. | Jastrzebska, I. and Morzycki, JW. 2017. Steroids. 127: 13-17. PMID: 28887171
- Solasodine reverses stemness and epithelial-mesenchymal transition in human colorectal cancer. | Zhuang, YW., et al. 2018. Biochem Biophys Res Commun. 505: 485-491. PMID: 30268504
- Two-step Synthesis of Solasodine Pivalate from Diosgenin Pivalate. | Wojtkielewicz, A., et al. 2019. Molecules. 24: PMID: 30901960
- The synthesis of solasodine F-homo-analogues. | Kiełczewska, U., et al. 2019. Org Biomol Chem. 17: 9050-9058. PMID: 31580372
- Solasodine, Isolated from Solanum sisymbriifolium Fruits, Has a Potent Anti-Tumor Activity Against Pancreatic Cancer. | Fan, Y., et al. 2021. Drug Des Devel Ther. 15: 1509-1519. PMID: 33888977
- Evaluation of a Chaotrope and Kosmotrope in the Multivariate Optimization of PHW-ATPE of Solasodine from Leaves of Solanum mauritianum. | Mokgehle, TM., et al. 2022. Molecules. 27: PMID: 36080313
- Orally administered solasodine, a steroidal glycoalkaloid, suppresses ovalbumin-induced exaggerated Th2-immune response in rat model of bronchial asthma. | Arora, P., et al. 2022. Chem Biol Interact. 366: 110138. PMID: 36084726
- Solasodine suppress MCF7 breast cancer stem-like cells via targeting Hedgehog/Gli1. | Chen, J., et al. 2022. Phytomedicine. 107: 154448. PMID: 36116198
- Ursolic Acid and Solasodine as Potent Anti-Mycobacterial Agents for Combating Paratuberculosis: An Anti-Inflammatory and In Silico Analysis. | Navabharath, M., et al. 2022. Molecules. 28: PMID: 36615467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Solasodine, 100 mg | sc-296408 | 100 mg | $178.00 | |||
Solasodine, 250 mg | sc-296408A | 250 mg | $333.00 |