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p-NOS3 Antibody (pS1177.39): sc-293032

 |  Datasheet

(Based on data analysis)
  • p-NOS3 Antibody (pS1177.39) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • recommended for detection of Ser 1177 phosphorylated NOS3 of human origin by WB
 

See additional NOS Antibodies including NOS, NOS1, pan NOS, NOS2, NOS2B and NOS3.

Also see NOS3 Inhibitors for functional analysis of cellular responses to NOS3.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-NOS3 Antibody (pS1177.39) sc-293032 200 µg/ml $279
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human NOS3 4846 7q36.1 NM_000603, NM_001160109, NM_001160110, NM_001160111 NP_000594
 601367
 

Nitric oxide (NO) has a broad range of biological activities and has been implicated in signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOSs), the enzymes responsible for synthesis of NO, contain an N-terminal oxygenase domain and a C-terminal reductase domain. NOS activity requires homodimerization as well as three cosubstrates (L-arginine, NADPH and O2) and five cofactors or prosthetic groups (FAD, FMN, calmodulin, tetrahydrobiopterin and heme). Several distinct NOS isoforms have been described and been shown to represent the products of three distinct genes. These include two constitutive Ca2+/CaM-dependent forms of NOS, including NOS1 (also designated ncNOS) whose activity was first identified in neurons, and NOS3 (also designated ecNOS), first identified in endothelial cells. The inducible form of NOS, NOS2 (also designated iNOS), is Ca2+-independent and is expressed in a broad range of cell types.