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SESN2 Antibody (H-62): sc-292558

 |  Datasheet

(Based on data analysis)
  • SESN2 Antibody (H-62) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 45-106 mapping near the N-terminus of SESN2 of human origin
  • recommended for detection of SESN2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
 
Full-length SESN2 protein sequence with immunogen highlighted:
MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGPSAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLSEINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDEGTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAPPTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRAIWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT

See additional SESN Antibodies.

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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
SESN2 Antibody (H-62) sc-292558 200 µg/ml $279
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SESN2 83667 1p35.3 NM_031459 P58004
 607767
 

SESN2, also known as sestrin 2, HI95, SES2 or SEST2, is a 480 amino acid protein that belongs to the sestrin family of PA26-related proteins. Expressed in a variety of tissues throughout the body, SESN2 is thought to be involved in the regulation of cell growth and survival and may play a role in mediating stress-induced cellular responses. SESN2 expression is upregulated following oxidative stress or DNA damage. This leads to cell toxicity and subsequent apoptosis, implying an essential role for SESN2 in the regulation of cell viability. Conversely, overexpression of SESN2 in breast cancer cells leads to protection from apoptosis, suggesting a possible role for SESN2 in tumor progression. SESN2 is, therefore, a crucial regulator of cell survival whose function varies depending on cellular conditions.