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- Specifications
- Offered as 5 g (sc-29070)
- CAS Number: 64-75-5
- Molecular Weight: 480.90
- Molecular Formula: C22H24N2O8 ·HCl
- Form: Solid
- Solubility: Mixes with water.
- SMILES: Cl.CN(C)C1C2CC3C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(
O)C2(O)C(=O)C(C(N)=O)=C1O
- Description
- Tetracycline HCL belongs to a family of broad-spectrum antibiotics that inhibit protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to the bacterial ribosome and has been used in a variety of root canal studies. In Tick-Borne Encephalitis virus (TBEV) studies, tetracycline HCL increased the concentrations of sIL-6R, IL-1RA, sTNFR1 and decreased the levels of TNF-α. Studies show that tetracycline can induce cold shock response and enhance expression of P450s proteins. Compounds that both inhibit protein synthesis and induce a cold shock response, could potentially act as protein synthesis enhancers under determined conditions.
- Usage
- Use at a concentration of 15 μg/ml
- Safety
- Risk Statements: R60,R61,R23,R24,R25,R36,R37,R38,R42,R43
- Safety Statements: S36,S37,S39
- For Research Use Only
- Reference Numbers
- PubChem Compound ID: 9848033
- MDL Number: MFCD00078142
- EC Number: 200-593-8
- References
- 1. Chopra, I., et al. 1978. Microbiol. Rev. 42: 707-724. PMID: 739968
2. Kusano, K., et al. 1999. Arch. Biochem. Biophys. 367: 129-136. PMID: 10375408
3. Guan, J., et al. 2002. Zhonghua Bing Li Xue Za Zhi. 31: 135-139. PMID: 12419161
4. Atrasheuskaya, A.V., et al. 2003. Clin. Exp. Immunol. 131: 148-154. PMID: 12519399
5. Wu, Y. and Fassihi, R. 2005. Int J Pharm. 290: 1-13. PMID: 15664125
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Tetracycline HCl
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