Tetracycline HCl (CAS 64-75-5)

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Application:	An antiobiotic that inhibits protein synthesis in bacteria
CAS Number:	64-75-5
Molecular Weight:	480.90
Molecular Formula:	C₂₂H₂₄N₂O₈ HCl

Description

Tetracycline HCL belongs to a family of broad-spectrum antibiotics that inhibit protein synthesis in bacteria by blocking the binding of aminoacyl-tRNA to the bacterial ribosome and has been used in a variety of root canal studies. In Tick-Borne Encephalitis virus (TBEV) studies, tetracycline HCL increased the concentrations of sIL-6R, IL-1RA, sTNFR1 and decreased the levels of TNF-α. Studies show that tetracycline can induce cold shock response and enhance expression of P450s proteins. Compounds that both inhibit protein synthesis and induce a cold shock response, could potentially act as protein synthesis enhancers under determined conditions.

Usage

Use at a concentration of 15 μg/ml

Technical Information

Physical State:	Solid
Solubility:	Soluble in water (10 mg/ml), DMSO, methanol, 0.1 N HCl (10 mg/ml), and ethanol. Insoluble in ether, and hydrocarbons.
Storage:	Store at -20° C
Melting Point:	220-223 °C (lit.)
Boiling Point:	799.4 °C at 760 mmHg (Predicted)

Safety and Reference Information

WGK Germany:	2
RTECS:	QI9100000
PubChem CID:	9848033
Merck Index:	14: 9196
MDL Number:	MFCD00078142
EC Number:	200-593-8
Beilstein Registry:	3844873
SMILES:	Cl.CN(C)C1C2CC3C(C(=O)C4=C(O)C=CC=C4[C@@]3(C)O)=C(O)C2(O)C(=O)C(C(N)=O)=C1O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

References

1. Chopra, I., et al. 1978. Microbiol. Rev. 42: 707-724. PMID: 739968
2. Kusano, K., et al. 1999. Arch. Biochem. Biophys. 367: 129-136. PMID: 10375408
3. Guan, J., et al. 2002. Zhonghua Bing Li Xue Za Zhi. 31: 135-139. PMID: 12419161
4. Atrasheuskaya, A.V., et al. 2003. Clin. Exp. Immunol. 131: 148-154. PMID: 12519399
5. Wu, Y. and Fassihi, R. 2005. Int J Pharm. 290: 1-13. PMID: 15664125

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