Molecular structure of Azaserine, CAS Number: 115-02-6
Azaserine (CAS 115-02-6)
See product citations (15)
Alternate Names:
AZS; O-Diazoacetyl-L-serine
Application:
Azaserine is a hexosamine biosynthesis inhibitor
CAS Number:
115-02-6
Purity:
≥98%
Molecular Weight:
173.13
Molecular Formula:
C5H7N3O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Azaserine is an inhibitor of the rate limiting step of the hexosamine biosynthethic pathway (HBP) and an irreversible inhibitor of GGT1 (gamma-Glutamyltranspeptidase). Independent of inhibiting the HBP pathway, azarine studies have demonstrated that it can protect against hyperglycemic endothelial damage through its antioxidant effect. Azarine and acivicin (sc-200498), another GGT inhibitor, bind to GGT at its substrate-binding pocket. The compound may act to elevate the SOD-2 (manganese-superoxide dismutase (MnSOD)) protein level as well as inhibit the oxidative stress and the expression of VCAM-1 and ICAM-1 in response to TNFalpha. Research indicates that azaserine has the potential to be used as a probe for identifying the L-(leucine-favoring) system transporter in human T-lymphocytes.
Azaserine (CAS 115-02-6) References
- Mutagenic effect of azaserine in relation to azaserine resistance in Escherichia coli. | IYER, VN. and SZYBALSKI, W. 1959. Science. 129: 839-40. PMID: 13635022
- Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro. | Hull, RL., et al. 2007. Am J Physiol Cell Physiol. 293: C1586-93. PMID: 17804609
- Crystal structures of Escherichia coli gamma-glutamyltranspeptidase in complex with azaserine and acivicin: novel mechanistic implication for inhibition by glutamine antagonists. | Wada, K., et al. 2008. J Mol Biol. 380: 361-72. PMID: 18555071
- The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects. | Rajapakse, AG., et al. 2009. Am J Physiol Heart Circ Physiol. 296: H815-22. PMID: 19136606
- Inhibition by neurotensin of azaserine-induced carcinogenesis in rat pancreas. | Tatsuta, M., et al. 1991. Int J Cancer. 47: 408-12. PMID: 1993548
- Potentiation of azaserine by cholestyramine in the rat. | Morgan, RG., et al. 1990. Int J Exp Pathol. 71: 485-91. PMID: 2400737
- Quantification of Azaserine-Induced Carboxymethylated and Methylated DNA Lesions in Cells by Nanoflow Liquid Chromatography-Nanoelectrospray Ionization Tandem Mass Spectrometry Coupled with the Stable Isotope-Dilution Method. | Yu, Y., et al. 2016. Anal Chem. 88: 8036-42. PMID: 27441891
- Photoinhibition of 2-amino-2-carboxybicyclo[2,2,1]heptane transport by O-diazoacetyl-L-serine. An initial step in identifying the L-system amino acid transporter. | Segel, GB., et al. 1989. J Biol Chem. 264: 16399-402. PMID: 2789219
- Effects of acetylsalicylic acid on rats: An in vivo experimental study in azaserine-rat model. | Yildiz, H., et al. 2019. J Cancer Res Ther. 15: 231-236. PMID: 30880783
- Can Echinococcus Granulosus Infestation Prevent Pancreatic Cancer? An invivo Experimental Study. | Doğan, S., et al. 2023. Asian Pac J Cancer Prev. 24: 1307-1312. PMID: 37116153
- Azaserine: further evidence for DNA damage in Escherichia coli. | Williams-Hill, DM., et al. 1984. Mutat Res. 129: 153-64. PMID: 6390189
- Azaserine resistance in Escherichia coli: chromosomal location of multiple genes. | Williams, MV., et al. 1980. J Bacteriol. 143: 383-8. PMID: 6995438
- Azaserine: survival and mutation in Escherichia coli. | Kubitschek, HE. and Sepanski, RJ. 1982. Mutat Res. 94: 31-8. PMID: 7048085
- Dissimilar effect of the carcinogenic agent azaserine on pancreatic and hepatic polyamine metabolism in rats. | Löser, C., et al. 1995. Pancreas. 10: 44-52. PMID: 7899459
Inhibitor of:
AARD, AATC, AGXT2L1, AMAC1L1, APIP, ASCT2, ASNSD1, Asparagine synthetase, Aspartoacylase-3, BHMT2, biotinidase, CTPS, CTPS2, CTU2, DHDPSL, DHRS1, EG619597, GCAT, GFAT1, GFAT2, GGCT, GGT, Gl Syn, GLULD1, Glut14, Glutamate-Pyruvate Transaminase, GNA1, GNPDA2, GOT1L1, Isoc2b, LOC644196, MAT IIβ, Mpi, NAG, O-GlcNAc transferase, PPC-DC, PSAT1, QAPRTase, RhBG, sarcosine dehydrogenase, SLC38A10, SNAT1, SPINDLY, TDH, THNSL2, TRMT5, TYW1, UAP1L1, UROC1, VibH, and XylT-II.Activator of:
α4Gn-T, C3orf21, C3orf64, CTP Synthase 1, FGAM Synthase, Gap1, GAP1m, Glutamine-rich 1, KNP-I, MoCo Sulfurase, P5CR, PRPS1L1, and ST6GAL2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Azaserine, 50 mg | sc-29063 | 50 mg | $306.00 | |||
Azaserine, 250 mg | sc-29063A | 250 mg | $906.00 |