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Hydroxyurea (CAS 127-07-1)

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Synonym:Hydroxycarbamide
Application:Shown to induce apoptosis by inhibiting DNA synthesis via ribonucleotide reductase inhibition
CAS Number:127-07-1
Purity:≥99%
Molecular Weight:76.1
Molecular Formula:CH4N2O2
Refer to Certificate of Analysis for lot specific data (including water content).
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Product NameCatalog #UnitPriceQtyAddFavorites
Hydroxyurea sc-29061 5 g $65
Hydroxyurea sc-29061A 25 g $240
Description
Hydroxyurea is a demonstrated antineoplastic agent, which is believed to block DNA replication by inhibiting R1 and R2 (ribonucleotide reductase) via destruction of the free radical at the enzymes active site. Induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53.
Additional Images
Hydroxyurea: sc-29061. Western blot detection of Cdc2 p34 phosphorylation using Saos-2 cells treated with Hydroxyurea: sc-29061. Blots were probed with Cdc2 p34 (B-6): sc-8395 (A), p-Cdc2 p34 (Tyr 15)-R: sc-7989-R preincubated with cognate phosphorylated peptide (B) and p-Cdc2 p34 (Tyr 15)-R: sc-7989-R pre-incubated with identical unphosphorylated peptide (C).
Hydroxyurea: sc-29061. Western blot analysis of phosphorylated Cdc2 p34 expression in HeLa (A) and Hydroxyurea-treated: sc-29061 HeLa (B) whole cell lysates. Antibody tested: p-Cdc2 p34 (Tyr 15): sc-7989.
Technical Information
Appearance:Crystalline powder
Physical State:Solid
Solubility:Soluble in water (50 mg/ml), hot alcohol (freely), and DMSO.
Storage:Store at 4° C
Melting Point:135 °C
Boiling Point:244.72 °C at 760 mmHg (Predicted)
Density:1.46 g/cm3 (Predicted)
Refractive Index:n20D 1.50 (Predicted)
IC50:L1210: IC50 = 21.38 µM (mouse); P388: IC50 = 32 µM (mouse)
Ki Data:Carbonic anhydrase IV: Ki= 113 µM (human); Carbonic anhydrase IX: Ki= 23 µM (human); Carbonic anhydrase II: Ki= 28 µM (human); Carbonic anhydrase VA: Ki= 31 µM (human)
pK Values:pKa: 10.56 (Predicted)
Safety and Reference Information
WGK Germany:3
RTECS:YT4900000
PubChem CID:3657
Merck Index:14: 4848
MDL Number:MFCD00007943
EC Number:204-821-7
Beilstein Registry:1741548
SMILES:NC(=O)NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
References
1. Anand, S., et al. 1995. Cancer Lett. 88: 101-105. PMID: 7850765
2. Davies, B.W., et al. 2009. Mol. Cell. 36: 845-860. PMID: 20005847
3. Lu, X., et al. 2010. Cancer Sci. 101: 609-615. PMID: 20028385
4. Gui, C.Y., et al. 1997. Cell Res. 7: 91-97. PMID: 9261566
5. Hendricks, S.P. and Mathews, C.K. 1998. J. Biol. Chem. 273: 29519-29523. PMID: 9792659
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