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- Specifications
- Offered as 100 mg (sc-29059) and 5 g (sc-29059A) sizes
- CAS Number: 50-02-2
- Molecular Weight: 392.5
- Molecular Formula: C22H29FO5
- Purity: 99%
- Form: Solid
- Physical Appearance: White solid
- Solubility: Soluble in ethanol (25 mg/mL) and DMSO (25 mg/mL)
- SMILES: CC1CC2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3(F)[C@@H](O)C
[C@]2(C)C1(O)C(=O)CO
- Description
- An anti-inflammatory glucocorticoid that induces the production of phospholipase A2 inhibitory protein (lipocortin). It also inhibits induction of nitric oxide synthase (IC50=5 nM). Dexamethasone has been shown to cause reduction in cyclin A and Cdk2 activity, inhibition of G1/S transition in osteoblasts and inhibition of phosphorylation of Rb protein. Dexamethasone has been observed to induce apoptosis in human thymocytes and eosinophils but to inhibit apoptosis in neutrophils.
- Usage
- Recommended working concentration: 500-1000 nM
- Safety
- Risk Statements: R61,R62,R36,R37,R38,R43
- Safety Statements: S26,S22,S45,S36,S37,S1,S2
- For Research Use Only
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
- Reference Numbers
- PubChem Compound ID: 5743
- MDL Number: MFCD00064136
- EC Number: 200-003-9
- References
- 1. Clark, M.A., et al. 1986. Prostaglandins. 32: 703-708. PMID: 3103170
2. Moncada, S., et al. 1991. Trends Pharmacol. Sci. 12: 130-131. PMID: 1712139
3. Fearnhead, H.O., et al. 1994. Biochem. Pharmacol. 48: 1073-1079. PMID: 7945400
4. Chauhan, D., et al. 2000. J. Biol. Chem. 275: 27845-27850.PMID: 1088051
5. Jaiswal, N., et al. 1997. J. Cell. Biochem. 64: 295-312. PMID: 9027589
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Dexamethasone
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