epitope corresponding to amino acids 195-416 mapping near the C-terminus of OMG of human origin
recommended for detection of OMG of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
OMG Background Information Oligodendrocyte myelin glycoprotein (OMG, OMgp) is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes that influences the development of the adult central nervous system (CNS). OMG inhibits neurite outgrowth through its interaction with the Nogo receptor. This function requires its leucine-rich repeat domain, a highly-conserved region in OMG that influences cell proliferation, formation and maintenance of myelin sheaths. OMG inhibits neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC-12 cells.
OMG (H-222)
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OMG (H-222): sc-28948. Western blot analysis of OMG expression in NIH/3T3 (A) and SK-N-MC (B) whole cell lysates.
OMG (H-222): sc-28948. Western blot analysis of OMG expression in non-transfected 293T: sc-117752 (A), mouse OMG transfected 293T: sc-125735 (B) and NIH/3T3 (C) whole cell lysates.
OMG (H-222): sc-28948. Western blot analysis of OMG expression in non-transfected: sc-117752 (A) and truncated human OMG transfected: sc-170075 (B) 293T whole cell lysates.
OMG (H-222): sc-28948. Western blot analysis of OMG expression in IMR-32 whole cell lysate.
