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Alkaline Phosphatase (H-330) Antibody: sc-28904 |
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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 31-330 mapping near the N-terminus of PLAP of human origin
- recommended for detection of PLAP, ALP-1, IAP, EAP and TNSALP and partially cross-reactive with other alkaline phosphatases of mouse, rat and human origin by WB, IP, IF and ELISA
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Alkaline Phosphatase Background Information
Alkaline phosphatases (AP) are glycosyl-phosphatidylinositol (GPI)-anchored, dimeric, Zn2+-metallated glycoproteins that catalyze the hydrolysis of phosphomonoesters into an inorganic phosphate and an alcohol. Placental alkaline phosphatase (also known as PLAP, ALPP, PALP, placental ALP-1 or Regan isozyme) is a 530 amino acid, tissue-specific AP that is expressed in the placenta, the serum of pregnant women and ectopically expressed in various cancers, including those of the ovary and testis. PLAP may assist in guiding migratory cells and transporting specific molecules, such as fatty acids and immunoglobulins, across the plasma membrane. The three tissue-specific APs identified in human, PLAP, germ cell AP (GCAP) and intestinal AP, are 90-98% homologous and their genes are clustered on chromosome 2q. |
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Alkaline Phosphatase (H-330)
Click on image to enlarge
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PLAP (H-300): sc-28904. Western blot analysis of PLAP expression in JAR whole cell lysate.
PLAP (H-300): sc-28904. Western blot analysis of PLAP expression in mouse heart (A) and mouse placenta (B) tissue extracts.
PLAP (H-300): sc-28904. Western blot analysis of PLAP expression in non-transfected: sc-117752 (A) and human PLAP transfected: sc-113546 (B) 293T whole cell lysates. |
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