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PKA Iα/β reg Antibody (H-90): sc-28893

 |  Datasheet

(Based on data analysis)

  • PKA Iα/β reg Antibody (H-90) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope corresponding to amino acids 246-335 mapping within an internal region of PKA Iα reg of human origin
  • recommended for detection of PKA Iα and Iβ reg of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • See 1 citations for PKA Iα/β reg Antibody (H-90)
 
Full-length PKA Iα/β reg protein sequence with immunogen highlighted:
MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV

See additional PKA Antibodies including PKA, PKA alpha cat, PKA beta cat, PKA gamma cat, PKA I alpha reg, PKA I beta reg, PKA II alpha reg, PKA II beta reg and PKA Phosphopeptide Substrate.

Also see chemical PKA Inhibitors, chemical PKA Activators or chemical PKA Substrates for functional analysis of cellular responses to PKA.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PKA Iα/β reg Antibody (H-90) sc-28893 200 µg/ml $279
 CRISPR/Cas9 KO and HDR Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PKA Iα reg CRISPR/Cas9 KO Plasmid (m) sc-422400 20 µg $345
PKA Iα reg HDR Plasmid (m) sc-422400-HDR 20 µg $385
PKA Iα reg CRISPR/Cas9 KO Plasmid (h) sc-402036 20 µg $345
PKA Iα reg HDR Plasmid (h) sc-402036-HDR 20 µg $385
PKA Iβ reg CRISPR/Cas9 KO Plasmid (m) sc-422401 20 µg $345
PKA Iβ reg HDR Plasmid (m) sc-422401-HDR 20 µg $385
PKA Iβ reg CRISPR/Cas9 KO Plasmid (h) sc-418321 20 µg $345
PKA Iβ reg HDR Plasmid (h) sc-418321-HDR 20 µg $385
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PKA Iβ reg (h2): 293T Lysate sc-112159 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PRKAR1A 5573 17q24.2 NM_002734, NM_212471, NM_212472 P10644
610489
Human PRKAR1B 5575 7p22.3 NM_002735 P31321
176911
Mouse Prkar1a 19084 11 E1 Q9DBC7
N/A
Mouse Prkar1b 19085 5 G2 P12849
N/A
 


The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme, resulting in release of active catalytic subunits. Four different PKA regulatory subunits have been identified, designated Iα, Iβ, IIα and IIβ. The PKA Iα reg protein is a tissue-specific extinguisher that downregulates the expression of seven liver genes in heptoma x fibroblast hybrids. Functional null mutations in the gene that codes for PKA Iα reg cause Carney complex (CNC). CNC is an autosomal dominant multiple neoplasia syndrome. CNC is associated with a variety of characterized symptoms such as cardiac and other myxomas, spotty skin pigmentation, endocrine tumors and psammamatous melanotic schwannomas.

PKA Iα/β reg Antibody (H-90) Product Citations
See how others have used PKA Iα/β reg Antibody (H-90) and or PKA Iα/β reg Antibody (H-90) conjugates.


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PKA Iα/β reg Antibody (H-90) Data
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PKA Iα/β reg (H-90): sc-28893. Western blot analysis of PKA Iα reg expression in non-transfected: sc-117752 (A) and mouse PKA Iα reg transfected: sc-110206 (B) 293T whole cell lysates.
PKA Iα/β reg (H-90): sc-28893. Western blot analysis of PKA Iα reg expression in non-transfected: sc-117752 (A) and human PKA Iα reg transfected: sc-111596 (B) 293T whole cell lysates.
PKA I7α/β reg (H-90): sc-28893. Western blot analysis of PKA Iβ reg expression in non-transfected: sc-117752 (A) and human PKA Iβ reg transfected: sc-112159 (B) 293T whole cell lysates.
PKA Iα/β reg (H-90): sc-28893. Western blot analysis of PKA Iβ reg expression in non-transfected: sc-117752 (A) and mouse PKA Iβ reg transfected: sc-125829 (B) 293T whole cell lysates.
PKA Iα/β reg (H-90): sc-28893. Western blot analysis of PKA Iα/β reg expression in SW-13 whole cell lysate.
PKA Iα/β reg (H-90): sc-28893. Western blot analysis of PKA Iα/β reg expression in non-transfected 293T: sc-117752 (A), human PKA Iα/β reg transfected 293T: sc-177734 (B) and CCRF-CEM (C) whole cell lysates.
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