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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-80 mapping at the N-terminus of KCNE3 of human origin
- recommended for detection of KCNE3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
KCNE3 |
10008 |
11q13.4 |
NM_005472 |
Q9Y6H6
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604433 |
| Mouse |
Kcne3 |
57442 |
7 E2 |
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Q9WTW2
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N/A |
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KCNE3 Background Information
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. KCNE3 (potassium voltage-gated channel, Isk-related family, member 3), also known as HYPP, potassium channel subunit beta MiRP2 or HOKPP, is a 103 amino acid single-pass type I membrane protein belonging to the potassium channel KCNE family. Expressed predominantly in kidney, KCNE3 is also found at moderate levels in small intestine and associates with a voltage-gated potassium channel complex to regulate stability and gating kinetics. The gene encoding KCNE3 maps to human chromosome 11q13.4; defects in which are the cause of an autosomal dominant disorder known as periodic paralysis hypokalemic (or HOKPP), a muscular disorder known as thyrotoxic periodic paralysis type 1 (TTPP1) and Brugada syndrome type 6 (BRS6).
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KCNE3 (H-80)
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KCNE3 (H-80): sc-28796. Western blot analysis of human recombinant KCNE3 fusion protein.
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