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GABAA Rβ1/2/3 (H-50) Antibody: sc-28794 |
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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 26-75 mapping within an extracellular domain of GABAA Rβ1 of human origin
- recommended for detection of GABAA Rβ1, 2 and 3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
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GABAA Rβ1/2/3 Background Information
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (g-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Rå1-6, GABAA R ∫1-3, GABAA R©1-3, GABAA R∂, GABAA Ré, GABAA Rρ1 and GABAA Rρ2. The GABAB family is composed of GABAB R1å and GABAB R1∫. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2 and -3). The GABA transporters function to terminate GABA action. |
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GABAA Rβ1/2/3 (H-50)
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GABAA Rb1/2/3 (H-50): sc-28794. Western blot analysis of GABAA Rb1/2/3 expression in 293 (A) and EOC 20 (B) whole cell lysates.
GABA A Rβ1/2/3 (H-50): sc-28794. Western blot analysis of GABA A Rβ3 expression in non-transfected: sc-117752 (A) and human GABA A Rβ3 transfected: sc-173039 (B) 293T whole cell lysates. |
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