epitope corresponding to amino acids 1-127 representing full length Pol II RPB6 of human origin
recommended for detection of Pol II RPB6 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
Pol II RPB6 Background Information RNA polymerase II (Pol II) is a multi-subunit enzyme responsible for the transcription of protein-coding genes. Transcription initiation requires recruitment of the complete transcription machinery to a promoter via solicitation by activators and chromatin remodeling factors. Pol II can coordinate 10 to 14 subunits. This complex interacts with the promoter regions of genes and a variety of elements and transcription factors. The DNA binding domain of the polymerase is a groove where TFIIB orients the DNA for unwinding and transcription.
Pol II RPB6 (FL-127)
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Pol II RPB6 (FL-127): sc-28711. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
Pol II RPB6 (FL-127): sc-28711. Immunoperoxidase staining of formalin fixed, paraffin-embedded human urothelial cancer tissue showing nuclear staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
