Mitomycin C (4% in NaCl) (CAS 50-07-7 (non-salt))
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Mitomycin C (4% in NaCl) is a reagent used to generate mitotically inactive feeder cells in culture. Mitomycin C (4% in NaCl) is a DNA crosslinking agent which inhibits DNA synthesis and causes apoptosis via a p53-dependent pathway. This compound is activated by sodium dithionite which is thought to cause bifunctional alkylation of DNA. In addition, when added to Micrococcus luteus DNA Mitomycin C (4% in NaCl) forms adducts between itself and deoxyguanosine residues. In laboratory applications, it has been employed to investigate the impact of antibiotics on cells. The mechanism of action of Mitomycin C (MMC) involves hindering DNA synthesis in bacterial cells. This is accomplished by its binding to DNA polymerase, the enzyme responsible for DNA synthesis. By preventing the polymerase from generating new DNA strands, bacterial growth is impeded.
Mitomycin C (4% in NaCl) (CAS 50-07-7 (non-salt)) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Mitomycin C (4% in NaCl), 50 mg | sc-286964 | 50 mg | $209.00 |