epitope corresponding to amino acids 181-236 mapping at the C-terminus of ASCL1 of human origin
recommended for detection of ASCL1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-28688 X, 200 µg/0.1 ml
ASCL1 Background Information The mammalian homolog of the Drosophila protein achaete-scute, ASCL1 (also known as ASH1) is a basic helix-loop-helix transcription factor that is required for early development of the nervous system. Expressed in fetal brain, ASCL1 is essential for the proper development of autonomic neurons and for the survival of subsets of autonomic neurons. ASCL1 interaction with MEF-2A may regulate the expression of specific genes that are critical for the formation of distinct neuronal circuits within the central nervous system. The high level of ASCL1 expression in neuroendocrine tumors, such as medullary thyroid cancer, small cell lung cancer and lung cancer with neuroendocrine features may provide a useful marker for cancers with neuroendocrine features. Mapping to human chromosome 12, the ASCL1 gene contains a trinucleotide repeat region, making this locus a candidate for inherited disease.
ASCL1 (H-56)
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ASCL1 (H-56): sc-28688. Western blot analysis of ASCL1 expression in non-transfected: sc-117752 (A) and human ASCL1 transfected: sc-171675 (B) 293T whole cell lysates.
ASCL1 (H-56): sc-28688. Western blot analysis of ASCL1 expression in C32 whole cell lysate.
