epitope corresponding to amino acids 628-745 mapping at the C-terminus of A-Myb of human origin
recommended for detection of A-Myb of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-28686 X, 200 µg/0.1 ml
A-Myb Background Information The Myb family of transcription factors, which includes the structurally related A-, B-, and c-Myb genes, regulate differentiation and cellular growth through binding to promoters with the consensus sequence PyAAC(G/T)G and transactivating gene expression. c-Myb is the cellular homolog of the leukemogenic avian retroviral protein v-Myc. c-Myb is expressed predominantly in immature and rapidly dividing hematopoietic cells, and cellular levels of c-Myb substantially decreases as cells reach terminal differentiation. B-Myb is expressed in a wide variety of proliferating cells, with levels accumulating during the G1 to S phase transition. A-Myb is expressed at specific times in reproductive tissues, some neural cells, and a subset of normal and neoplastic B lymphocytes. Both A-Myb and B-Myb are expressed in t(14:18) lymphoma cells where they then inhibit cell arrest and apoptotic signaling. Expression of B-Myb rescues cells from p53-induced G1 phase arrest that is mediated by p21, while A-Myb functions as an anti-apoptotic factor by effectively activating the bcl-2 promoter and thereby up-regulating Bcl-2 expression.
A-Myb (H-125) Product Citations
See how others have used A-Myb (H-125): sc-28686 antibody and or A-Myb (H-125) antibody conjugates.
