epitope corresponding to amino acids 186-250 of RUNX1 of human origin
recommended for detection of a broad range of RUNX1 isoforms of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-28679 X, 200 µg/0.1 ml
RUNX1 Background Information The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2åB, CBFA2), RUNX2 (also designated AML-3, PEBP2åA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPåC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is involved in hematopoiesis and is frequently targeted in human leukemia by chromosomal translocations that fuse the DNA-binding domain of RUNX1 to other transcription factors and corepressor molecules. In addition to its role in leukemogenesis, RUNX1 is also involved in sensory neuron diversification. Specifically, RUNX1 promotes axonal growth, is selectively expressed in neural crest-derived TrkA+ sensory neurons and mediates TrkA transactivation in migratory neural crest cells. Alternative splicing gives rise to several isoforms of RUNX1.
RUNX1 (H-65) Product Citations
See how others have used RUNX1 (H-65): sc-28679 antibody and or RUNX1 (H-65) antibody conjugates.
