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home » Kinases and Phosphatases » LKB1 Antibody / LKB1 Antibodies » p-LKB1 (Ser 431)-R: sc-28465-R

p-LKB1 (Ser 431)-R Antibody: sc-28465-R

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to phosphorylated Ser 431 of LKB-1 of mouse origin
  • recommended for detection of Ser 431 phosphorylated LKB1 of mouse, rat and human origin by WB, IP, IF and ELISA; may cross-react with phosphorylated H+/K+ ATPase α1
  • blocking peptide, sc-28465 P
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
p-LKB1 (Ser 431) P sc-28465 P
(peptide)
 100 µg/0.5 ml $61
p-LKB1 (Ser 431)-R sc-28465-R 200 µg/ml $279
Lambda Phosphatase sc-200312 100,000 units $462
Lambda Phosphatase sc-200312A 20,000 units $116

LKB1 Background Information
Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid serine/threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers. Phosphorylation of LKB1 at Ser431 by p90(RSK) and cAMP-dependent protein kinase is essential for LKB1 to suppress cell growth.

p-LKB1 (Ser 431)-R Product Citations
See how others have used p-LKB1 (Ser 431)-R: sc-28465-R antibody and or p-LKB1 (Ser 431)-R antibody conjugates.


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p-LKB1 (Ser 431)-R
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sc-28465
Western blot analysis of LKB1 phosphorylation in untreated (A,C)and lambda protein phosphatase (sc-200312A) treated (B,D) Caki-1 whole cell lysates. Antibodies tested include p-LKB1 (Ser 431): sc-28465 (A,B) and LKB1 (Ley 37D/G6): sc-32245 (C,D).
sc-28465
Western blot analysis of LKB1 phosphorylation in untreated (A,C) and lambda protein phosphatase treated (B,D) NIH/3T3 whole cell lysate. Antibodies tested include p-LKB1 (Ser 431)-R: sc-28465-R (A,B) and LKB1 (Ley 37D/G6): sc-32245 (C,D).
sc-28465
Western blot analysis of LKB1 phosphorylation in untreated (A,D), PMA treated (B,E) and PMA and lambda protein phosphatase (sc-200312A) treated (C,F) Jurkat whole cell lysates. Antibodies tested include p-LKB1 (Ser 431)-R: sc-28465-R (A,B,C) and LKB1 (Ley 37D/G6): sc-32245 (D,E,F).
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