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p-Unc18-1 (Ser 313)-R Antibody: sc-28459-R |
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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to phosphorylated Ser 313 of Unc18-1 of human origin
- recommended for detection of Ser 313 phosphorylated Unc18-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, bovine, porcine and avian
- blocking peptide, sc-28459 P
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Unc18-1 Background Information
Unc18-1, 2, and 3 (syntaxin binding proteins 1-3, STXBP1-3, UNC18-a-c, MUNC18-1-3) are chaperone molecules that block syntaxin interactions with cognate SNARE (soluble NSF attachment protein (SNAP) receptors) proteins and regulate exocytosis. Unc18-1-3 mRNA is present in RBL-2H3 mast cells, mouse bone marrow derived mast cells (BMMC), and platelets. Unc18-1 Ser-313 is a protein kinase C phosphorylation site and Thr-574 is a cyclin-dependent kinase 5 phosphorylation site that regulates Unc18-1/syntaxin1A interactions. Unc18-1 is phosphorylated on Ser-313 in response to phorbol ester treatment in adrenal chromaffin cells. Unc18-2 colocalizes with syntaxin 3 at the apical plasma membrane of intestinal, proximal tubule, and collecting duct epithelial cells. |
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p-Unc18-1 (Ser 313)-R
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p-Unc18-1 (Ser 313)-R: sc-28459-R. Western blot analysis of Unc18-1 phosphorylation in IMR-32 whole cell lysate. |
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