p-CaMKI (Thr 177)-R Antibody: sc-28438-R

CaMKI Background Information
The Ca++/calmodulin-dependent protein kinases (CaM kinases) are a structurally related subfamily of serine/threonine kinases that includes CaMKI, CaMKII and CaMKIV. CaMKII is a ubiquitously expressed serine/threonine protein kinase that is activated by Ca++and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes designated å,ß,©, and ∂ which may or may not be co-expressed in the same tissue type. CaMKIV is stimulated by Ca++ and CaM, but phosphorylation by a CaMK is also required for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40 fold increase in CaMKIV activity. An additional kinase, CaMKK functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.