p-Cdk (Thr14/Tyr15)-R Antibody: sc-28435-R

Cdk Background Information
The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. In humans, the cyclin-dependent protein kinase complex is essential for cell-cycle control and is comprised of catalytic and regulatory proteins that function as Ser/Thr protein kinases. The catalytic cyclins, four of which are designated Cdc2 p34, Cdk2, Cdk3 and Cdk5, function at different stages of the cell cycle. Together, these proteins catalyze the ATP-dependent reactions that allow the cell to progress through the G1/S-phase transition and, ultimately, through mitosis. The cyclin-dependent protein kinase complex is regulated by proteins such as p21 and p27 that associate with the complex and control its activity. Further regulation of the catalytic subunits is achieved via phosphorylation at residues such as Thr14 and Tyr15, an event that either activates or deactivates the target protein.