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p-LIMK-1/2 (Thr 508/505)-R Antibody: sc-28409-R |
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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to phosphorylated Thr 505 of LIMK-2 of human origin
- recommended for detection of Thr 508 phosphorylated LIMK-1 and Thr 505 phosphorylated LIMK-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-28409 P
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p-LIMK-1/2 Background Information
Proteins containing LIM motifs are typically involved in cell fate determination and growth control. A family of proteins designated LIM kinases, incuding LIMK-1 and LIMK-2, has been identified. LIMK-1 has been shown to regulate the stabilization of F-Actin structures and Cofilin activity, indicating that LIMK-1 plays a role in a signaling pathway involved in the regulation of cell motility and morphogenesis. LIMK-1 inhibits neuronal differentiation of PC12 cells and is thought to act by interfering with events downstream of MAPK activation. Expression patterns of LIMK-1 and LIMK-2 suggest that these proteins may have different functions during development. A truncated form of LIMK-2 has been identified in adult testis that is thought to arise from an alternative initiation exon. |
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p-LIMK-1/2 (Thr 508/505)-R
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p-LIMK-1/2 (Thr 508/505)-R: sc-28409-R. Western blot analysis of LIMK-1/2 phosphorylation in untreated (A) and PMA-treated THP-1 (B) whole cell lysates. Western blot analysis of LIMK-1/2 phosphorylation in untreated (A,D), PMA treated (B,E) and PMA and lambda protein phosphatase treated (C,F) THP-1 whole cell lysates. Antibodies tested includep-LIMK-1/2 (Thr 508/505)-R: sc-28409-R (A,B,C) and LIMK-1 (H-84): sc-5576 (D,E,F). |
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