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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 1-237 of Fos B of human origin
- recommended for detection of Fos B, ΔFos B and, to a lesser extent, c-Fos, Fra-1 and Fra-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine and canine
- TransCruz reagent for Gel Supershift and ChIP applications, sc-28213 X, 200 µg/0.1 ml
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Ordering InformationProduct Citations
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
FOSB |
2354 |
19q13.32 |
NM_006732 |
P53539
|
164772 |
| Mouse |
Fosb |
14282 |
7 A3 |
|
P13346
|
N/A |
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Fos B Background Information
The v-Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA TPA response elements (TREs), c-Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c-Fos, exhibits similar kinetics of expression as c-Fos and forms heterodimers with both c-Jun and Jun B, which bind to TRE DNA response elements. Functional homologs of c-Fos and Fos B include Fra-1 and Fra-2 genes.
| Fos B (H-237) Product Citations |
See how others have used Fos B (H-237): sc-28213 antibody and or Fos B (H-237) antibody conjugates.
3 total citations Loading citations.
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Fos B (H-237)
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Fos B (H-237): sc-28213. Immunoperoxidase staining of formalin-fixed, paraffin-embedded rat brain tissue showing nuclear staining of the Nucleus Accumbens area. Image kindly provided by Regina Vontell, Adrienne Betz and John Salamone, University of Connecticut.
Fos B (H-237): sc-28213. Western blot analysis of Fos B expression in non-transfected: sc-117752 (A) and human Fos B transfected: sc-112170 (B) 293T whole cell lysates. Fos B (H-237): sc-28213. Western blot analysis of Fos B expression in non-transfected: sc-117752 (A) and human Fos B transfected: sc-177246 (B) 293T whole cell lysates. |
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